For millions of people living with chronic pain, sports injuries, arthritis, and other musculoskeletal conditions, recovery is often a long and frustrating journey. Limited access to consistent treatment, repeated clinic visits, and dependence on pain medications can make healing more difficult, affecting mobility, independence, and overall quality of life. Without effective recovery solutions, many individuals struggle to return to the activities they enjoy and rely on every day.
ZetrOZ Systems was founded to address these challenges by making pain recovery more accessible, convenient, and effective. The company develops wearable, non-invasive medical technologies that help reduce pain, improve circulation, support tissue healing, and aid rehabilitation without surgery or opioid-based treatments.
Its flagship technology, SAM® (Sustained Acoustic Medicine), allows patients to receive long-duration therapeutic ultrasound treatment while continuing their daily routines. By combining clinical research, biomedical engineering, and patient-focused design, ZetrOZ Systems is helping transform the way recovery and rehabilitation are delivered across sports medicine, orthopedic care, military healthcare, and active aging populations.
ZetrOZ Systems at a Glance
- 46+ patents in therapeutic ultrasound and wearable bioelectronic medicine
- FDA-cleared multi-hour wearable ultrasound therapy
- Collaborations with NASA and the Department of Defense
- 100% U.S.-based manufacturing
- Arthritis Foundation Ease of Use Certification
- Utilized within VA healthcare systems
- Focused on helping 100 million patients through sustained acoustic medicine
Technology used across sports medicine, orthopedic rehabilitation, military healthcare, workers’ compensation, and active aging populations
The Mission Behind ZetrOZ Systems
Dr. George K. Lewis founded ZetrOZ Systems with a mission to help people recover from pain and injuries through safe, non-invasive medical technologies. Built on a strong foundation of medical research, engineering, and therapeutic ultrasound, the company focuses on improving healing, recovery, and long-term musculoskeletal health while helping patients stay active and independent.
To achieve this, ZetrOZ Systems developed SAM® (Sustained Acoustic Medicine), a wearable ultrasound therapy technology that allows patients to receive treatment beyond traditional clinical settings. By combining clinical science, innovation, and a patient-centered approach, the company provides practical solutions that help reduce pain, support tissue healing, and improve recovery outcomes. Today, ZetrOZ Systems serves patients, healthcare providers, athletes, military personnel, and aging populations with clinically validated, non-surgical and non-opioid recovery technologies.
Developing Recovery Solutions That Fit Everyday Life
ZetrOZ Systems recognized an important gap in the rehabilitation and pain recovery landscape. Many patients dealing with chronic musculoskeletal conditions and soft tissue injuries had limited access to consistent treatment, as traditional ultrasound therapy was often restricted to brief sessions in clinical settings. This made it difficult for patients to receive therapy as frequently as needed and maintain long-term treatment plans.
At the same time, healthcare providers were seeking proven alternatives to surgery and pain medications for managing recovery. In response, ZetrOZ Systems focused on developing a wearable, easy-to-use solution that could deliver therapy beyond the clinic while supporting ongoing healing and rehabilitation. The company also saw a growing need for recovery technologies that could fit seamlessly into everyday life, helping athletes, military personnel, active individuals, and aging populations receive effective treatment without sacrificing mobility, convenience, or flexibility.
Serving a Wide Range of Healthcare Sectors
ZetrOZ Systems specializes in developing wearable medical technologies that support pain relief, healing, and rehabilitation. At the center of its portfolio is sam®, an FDA-cleared wearable ultrasound therapy designed to deliver continuous treatment over several hours, giving patients greater flexibility and convenience throughout their recovery journey.
Built on years of research in therapeutic ultrasound, regenerative medicine, and biomedical engineering, sam® uses therapeutic ultrasound to improve circulation, promote tissue repair, reduce inflammation, and support the body’s natural healing process. Unlike traditional ultrasound treatments that are often limited to short clinic visits, sam® allows patients to receive therapy at home or while continuing their normal daily activities. This helps improve treatment consistency, making it easier for patients to stay on track with their recovery plans and achieve better long-term outcomes.
What further strengthens the technology is the company’s commitment to research and innovation. With more than 46 patents and collaborations with organizations such as NASA, the Department of Defense, and leading healthcare institutions, ZetrOZ Systems continues to advance practical recovery solutions backed by clinical studies and scientific validation.
Industries and patient populations served include:
- Orthopedic rehabilitation
- Sports medicine
- Physical therapy
- Military healthcare
- Workers’ compensation programs
- Active aging populations
By making long-duration therapy more accessible and convenient, ZetrOZ Systems is helping patients recover more effectively while improving mobility, independence, and overall quality of life.
A Practical Solution for Pain Relief, Recovery, and Mobility
sam® technology has become an important part of recovery and rehabilitation programs for individuals dealing with chronic pain of soft tissue injuries, including knee osteoarthritis, shoulder, ankle, and elbow tendinopathy. Its wearable design enables patients to continue therapy comfortably at home or while carrying out their daily activities, making treatment more convenient and consistent.
Key benefits of SAM® technology include:
- Long-duration wearable ultrasound therapy
- At-home treatment convenience
- Improved treatment consistency
- Reduced disruption to daily activities
- Support for pain relief and tissue healing
- Greater patient independence during recovery
The technology has proven particularly valuable for professional athletes, military personnel, and older adults seeking to manage pain and maintain mobility without disrupting their routines. Healthcare providers use sam® to support ongoing recovery plans, helping patients stay committed to treatment while promoting better long-term outcomes and greater independence.
Its effectiveness and ease of use have earned recognition from the Arthritis Foundation through its Ease of Use Certification. sam® has also been utilized within the VA healthcare system, further highlighting its role as a practical, accessible, and patient-friendly solution for pain recovery and rehabilitation.
An Ecosystem of Expertise:
ZetrOZ Systems plays an important role in advancing wearable medical technology through ongoing research, industry collaboration, and educational efforts. The company actively supports the development of better recovery and rehabilitation solutions by participating in clinical studies, healthcare initiatives, and professional forums focused on pain management, sports medicine, and musculoskeletal health.
Working closely with physicians, athletic trainers, rehabilitation specialists, healthcare organizations, and researchers, ZetrOZ Systems helps expand the understanding and adoption of sustained acoustic medicine. Its continued investment in clinical research and federally funded programs contributes to the growing body of evidence supporting therapeutic ultrasound and wearable recovery technologies. The company also places a strong emphasis on clinician education, providing healthcare professionals with the knowledge and practical tools needed to effectively integrate these technologies into patient care and recovery programs.
Strategic Partnerships
Collaboration has been a key part of ZetrOZ Systems’ growth and progress. The company has worked closely with organizations such as NASA, the Department of Defense, leading healthcare institutions, rehabilitation experts, and sports medicine professionals to advance research, strengthen clinical validation, and expand awareness of sustained acoustic medicine.
Beyond these partnerships, ZetrOZ Systems has built strong relationships with healthcare providers, VA healthcare systems, distributor networks, and athletic organizations. These collaborations help the company better understand patient and clinician needs while supporting the adoption of its technologies across a wide range of rehabilitation and recovery settings. By combining scientific research with real-world clinical insights, ZetrOZ Systems continues to advance wearable recovery solutions that make treatment more accessible, effective, and convenient for patients.
The Recognition Behind a Vision for Better Pain Recovery
ZetrOZ Systems has earned recognition as a trusted innovator in pain recovery and rehabilitation technology. The company’s reputation is built on a strong foundation of scientific research, clinical validation, and a commitment to developing solutions that deliver meaningful benefits to patients. This dedication is reflected in its FDA-cleared wearable ultrasound technology and a growing portfolio of more than 46 patents in therapeutic ultrasound and bioelectronic medicine.
One of the company’s most notable achievements is the success of sam® (Sustained Acoustic Medicine), which has received the Arthritis Foundation’s Ease of Use Certification and has been utilized within the VA healthcare system. These recognitions highlight the technology’s effectiveness, accessibility, and value for individuals seeking non-invasive recovery solutions.
Dr. Lewis has also helped position ZetrOZ Systems at the forefront of healthcare innovation through collaborations with respected organizations such as NASA, the Department of Defense, and leading healthcare institutions. Today, the company’s technology is used across sports medicine, orthopedic rehabilitation, military healthcare, and active aging communities, reflecting the growing trust healthcare professionals place in its ability to support recovery, improve mobility, and enhance quality of life.
A Commitment to Quality at Every Stage of Innovation
Patient safety, clinical excellence, and product reliability are at the heart of everything ZetrOZ Systems does. The company follows strict FDA regulations and comprehensive quality standards throughout every stage of product development, manufacturing, and commercialization to ensure its technologies meet the highest levels of safety and performance.
With all devices manufactured in the United States, ZetrOZ Systems maintains close control over quality, compliance, and production consistency. The company also invests heavily in clinical research and ongoing validation studies to ensure its technologies are backed by strong scientific evidence. By combining rigorous research with a patient-focused approach, ZetrOZ Systems continues to build trust among healthcare providers and patients while advancing safe, effective, and accessible recovery solutions.
The Next Generation of Pain Management and Recovery Solutions
Dr. George shares that the future of pain recovery and MedTech innovation is expected to be shaped by a growing shift toward patient-centered, technology-enabled care that extends beyond traditional clinical settings. As healthcare systems increasingly focus on long-term mobility, chronic condition management, and improved patient convenience, wearable medical technologies are becoming an essential part of the recovery process.
Another major trend is the rising demand for non-surgical and non-opioid treatment options that help patients recover safely while maintaining active and independent lifestyles. Clinically validated solutions that are easy to use, accessible, and adaptable to everyday life are likely to play a much larger role as more healthcare services move into home-based and remote care environments.
Over the next decade, wearable bioelectronic medicine and sustained therapeutic ultrasound are expected to drive significant advancements in rehabilitation and recovery. These technologies have the potential to make treatment more consistent, improve patient adherence, enhance recovery outcomes, and expand access to effective pain management solutions for a broader population.
Advice for Emerging Leaders, Entrepreneurs, and Innovators
ZetrOZ Systems believes that meaningful progress in healthcare comes from a long-term commitment to improving patient outcomes. Developing impactful medical technologies requires more than new ideas. It requires scientific rigor, clinical validation, strong collaboration, and a clear understanding of real-world patient needs. The company has built its approach around creating practical solutions that help people heal, recover, and live healthier lives.
The company believes that lasting success in the MedTech industry comes from focusing on patient needs rather than short-term market trends. By working closely with healthcare providers, understanding the challenges patients face, and continuously improving its technologies, ZetrOZ Systems strives to deliver solutions that create lasting value. Advancing healthcare technology takes dedication, patience, and persistence, but helping people reduce pain, regain mobility, and improve their quality of life makes the journey worthwhile.
Quick Takes
- One tool or app you would recommend to professionals in your industry:
- PubMed
- One quote that motivates you the most:
- “Innovation distinguishes between a leader and a follower.”
- One piece of advice you would offer to upcoming entrepreneurs or future business leaders:
- Build technologies that solve real clinical problems and improve patient outcomes.
- One movie or book you recommend everyone in business or leadership should experience:
- The Innovator’s Dilemma by Clayton Christensen.
ZetrOZ Systems’ 5 Impactful Business Mantras
- Put Patient Outcomes First: Every innovation should improve recovery, mobility, and quality of life.
- Make Healthcare More Accessible: Create solutions that fit seamlessly into everyday life and extend care beyond traditional settings.
- Let Science Lead the Way: Build trust through clinical research, proven results, and evidence-based development.
- Innovate with Purpose: Focus on solving real healthcare challenges with practical, non-invasive solutions.
- Commit to Continuous Improvement: Advance technology, strengthen partnerships, and keep raising the standard of patient care.
