Battling with acne and aging skin? You’re not alone—and the numbers prove it. Acne affects 9.4% of the global population, with up to 95% of teenagers in western countries experiencing breakouts, and 20% to 35% developing moderate-to-severe cases. But it doesn’t stop in adolescence—20% of adults aged 25 to 39 and nearly 10% of those between 40 and 64 still deal with acne.
At the same time, concerns about aging are growing, with nearly half of women, especially younger generations, feeling stressed about it. Healthy skin isn’t just about looking good—it’s about feeling good too. Our skin protects us from pollutants, bacteria, and harmful UV rays, but it also plays a huge role in confidence and mental well-being. Yet, finding a solution that tackles acne and aging can feel impossible.
Most products make you choose between fighting breakouts or reducing wrinkles, often leading to frustration with incomplete results. Worse, many formulas contain pore-clogging ingredients that do more harm than good. With more people searching for safe, effective, and science-backed skincare, the industry needs to do better—because you shouldn’t have to choose between clear skin and youthful skin.
Danielle Gronich, CEO of CLEARSTEM Skincare, is leading that change. She drives product innovation, research, and strategy, keeping the brand at the forefront of skincare science. Her expertise led to the development of the Acne Functional Lab Test—the first of its kind to identify nutrient imbalances linked to acne. Through clinical trials, CLEARSTEM’s products have shown a 75% improvement in acne, proving their effectiveness. Under Danielle Gronich’s leadership, CLEARSTEM has redefined skincare by prioritizing education, internal health, and clean, hormone-safe formulations. By partnering with dermatologists, wellness influencers, and major retailers, she has positioned CLEARSTEM as a trusted leader in the industry, helping customers achieve clear, youthful skin—without compromise.
A Skincare Revolution
CLEARSTEM is the first clinically effective skincare wellness routine formulated with zero pore-clogging ingredients, ever. Danielle Gronich and Co-Founder & CMO Kayleigh Christina struggled with cystic acne as adults and faced constant frustration in finding effective treatments. After years of trial and error, they discovered that the key to clear skin lies in addressing the root causes of acne rather than just treating the symptoms. They also found that many skincare products contain pore-clogging ingredients, making it difficult to find truly clean and effective solutions.
Danielle Gronich, known as The Acne GuruⓇ, battled cystic acne for over a decade before turning to clinical research. Determined to find answers, she opened the San Diego Acne Clinic in 2014, helping people of all ages and skin types achieve clear skin. Through her work, she saw the urgent need for safer, science-backed skincare solutions. This led her to partner with Kayleigh in 2017 to launch CLEARSTEM—a brand dedicated to delivering clean, results-driven skincare that treats acne and aging simultaneously.
Success Doesn’t Require a Perfect Plan
Danielle Gronich believes that success doesn’t require a perfect plan—just the courage to take the first step. CLEARSTEM didn’t begin with a grand business strategy. It started when Danielle Gronich, a skincare expert and clinic owner, met Kayleigh, a patient struggling with adult acne. Their shared passion for holistic health and frustration with ineffective treatments led them to create a product—initially just for clinic use. But when people saw real results, the demand grew, and so did their vision.
Instead of forcing growth, they listened to their community, adapted, and built a brand based on real needs. Their journey proves that you don’t have to have everything figured out to make an impact. If you see a problem worth solving, start. Trust the process, stay committed to your mission, and let your business evolve naturally.
Effective Acne & Anti-Aging Solutions
CLEARSTEM stands out by combining clean beauty, acne treatment, and anti-aging into one seamless approach. While many “clean” skincare products still contain hidden acne triggers and most acne treatments accelerate aging by over-drying the skin and compromising its natural barrier function, CLEARSTEM bridges this gap with formulations that support overall skin health. The brand goes beyond skincare by offering the first functional lab test designed to detect nutrient imbalances linked to acne, helping individuals address the root causes from within.
As the first clinically effective clean skincare routine targeting acne and aging, CLEARSTEM takes a holistic approach. It offers topical products, internal nutrition supplements, and personalized tools like the Pore Clogging Ingredients Checker and Acne Functional Lab Test. Education is also central to its mission, empowering individuals with the knowledge and resources needed to achieve long-term skin health—because clear skin changes everything.
Expert-Backed Formulations
CLEARSTEM collaborates with expert cosmetic chemists to ensure its formulations are effective and safe for acne-prone skin.
The team is dedicated to maintaining the highest standards through:
- Collaborating with expert cosmetic chemists.
- Monitoring beauty and wellness trends to stay ahead.
- Conducting clinical trials to prove product efficacy.
- Avoiding known hormone disruptors, parabens, phthalates, and acne-triggering ingredients.
Last year, CLEARSTEM conducted its first clinical trial to demonstrate the efficacy of its topical products—without any internal interventions—showing real, lasting results. While many brands bypass this step due to the significant investment of time and resources, CLEARSTEM remains committed to creating products that are clean and clinically effective.
Targeted Treatments for Every Skin Type
CLEARSTEM’s hero product, the MINDBODYSKIN Hormonal Acne Supplement, is the first clean internal alternative to harsh prescription acne medications. Danielle Gronich and Kayleigh were personally impacted by the limitations of traditional treatments—Danielle Gronich experienced unwanted side effects, while Kayleigh was unable to use them due to hormonal concerns. This supplement is designed to support clear skin from within by addressing nutrient imbalances and hormonal factors.
Among CLEARSTEM’s topical products, CELLRENEW Serum stands out as a key innovation. It was the brand’s first formulation using stem cells, combining clean ingredients with acne-safe technology to promote skin health.
With exciting new product launches and collaborations on the horizon, CLEARSTEM continues to expand its mission of providing holistic and effective skincare solutions.
Achieving Lasting, Healthy Skin
CLEARSTEM empowers people with the knowledge they need to take control of their skin health. Instead of relying on surface-level treatments, the company highlights the role of diet, vitamins, and ingredient awareness in managing acne. It also uses tailored bloodwork to uncover underlying triggers that traditional medicine often overlooks.
By bridging the gap between skincare and overall health, CLEARSTEM has changed the way acne is treated. This approach has empowered acne sufferers of all ages to achieve clear, healthy skin without harsh medications or ineffective products. Committed to reshaping the skincare industry, the company continues to provide people with the tools and education needed for lasting results.
Commitment to Excellence
CLEARSTEM is committed to delivering the highest standards of product safety and effectiveness. Unlike many skincare brands that rely solely on surface-level testing, CLEARSTEM goes the extra mile by conducting rigorous clinical trials to validate its formulations. One of the biggest challenges in this process was requiring participants to give blood on a monthly basis—a level of research most brands do not undertake. Yet, the dedication to uncovering real results paid off. An overwhelming 34 out of 35 participants successfully completed the trial, further proving the brand’s effectiveness and reinforcing its commitment to science-backed, results-driven skincare.
Expanding Horizons
CLEARSTEM continues to grow, exploring new ways to support acne and aging concerns.
This year, the company is focused on several key initiatives:
- Launching a new line of supplements to enhance skin health from within.
- Expanding its influencer marketing program to reach a wider audience.
- Partnering with key industry figures to introduce innovative skincare solutions.
Beyond skincare products, CLEARSTEM is dedicated to transforming how people understand and treat acne and aging. Rather than focusing solely on topical treatments, the company emphasizes education on root causes like nutritional deficiencies, food triggers, and chronic stress.
One of its most popular products, the MINDBODYSKIN Hormonal Acne Supplement, has gained viral attention as a natural alternative to prescription medications. Additionally, the Acne Functional Lab Test helps individuals identify key blood markers related to skin health, allowing them to address acne at its source.
Looking ahead, CLEARSTEM plans to expand its range of supplements and internal wellness solutions, providing more options for achieving clear, healthy skin. Through ongoing research, product development, and partnerships, the company remains committed to bridging the gap between skincare and overall wellness.
5 Powerful Business Mantras from Danielle Gronich
- Success Doesn’t Require a Perfect Plan: Take action, adapt, and let your business evolve based on real needs.
- Solve the Root Problem, Not Just the Symptoms: True innovation comes from addressing fundamental issues, not just quick fixes.
- Education is the Key to Empowerment: Knowledge transforms industries and creates a movement—not just a brand.
- Stay Committed to Excellence, Even When Others Take Shortcuts: True success comes from maintaining high standards and delivering real value.
- Listen, Learn, and Evolve with Your Community: The best businesses grow by engaging with their customers and innovating based on real-world feedback
